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Graphical contents list • MISCELLANEOUS PDF (547 K) | |||
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Aggregation and G-quadruplex DNA-binding study of 6a,12a-diazadibenzo-[a,g]fluorenylium derivative • SHORT COMMUNICATION Bernard Juskowiak, Elzbieta Galezowska, Natalia Koczorowska and Tadeusz W. Hermann SummaryPlus | Full Text + Links | PDF (281 K) | |||
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Discovery of small molecule antagonists of TRPV1 • SHORT COMMUNICATION Harshad K. Rami, Mervyn Thompson, Paul Wyman, Jeffrey C. Jerman, Julie Egerton, Stephen Brough, Alexander J. Stevens, Andrew D. Randall, Darren Smart, Martin J. Gunthorpe and John B. Davis SummaryPlus | Full Text + Links | PDF (338 K) | |||
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Biological evaluation of substituted quinolines • SHORT COMMUNICATION Xavier Franck, Alain Fournet, Eric Prina, Renaud Mahieux, Reynald Hocquemiller and Bruno Figadère SummaryPlus | Full Text + Links | PDF (256 K) | |||
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Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with Dimitrios Galanakis, Angeliki P. Kourounakis, Karyophyllis C. Tsiakitzis, Christos Doulgkeris, Eleni A. Rekka, Antonios Gavalas, Constantina Kravaritou, Christos Charitos and Panos N. Kourounakis SummaryPlus | Full Text + Links | PDF (254 K) | |||
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Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A2 inhibitors––reducing the lipophilicity of the arachidonyl chain isostere • SHORT COMMUNICATION Iain Walters, Colin Bennion, Stephen Connolly, Pamela J. Croshaw, Kim Hardy, Paul Hartopp, Clive G. Jackson, Sarah J. King, Louise Lawrence, Antonio Mete et al. SummaryPlus | Full Text + Links | PDF (268 K) | |||
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(±)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents • SHORT COMMUNICATION Ma SummaryPlus | Full Text + Links | PDF (255 K) | |||
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Structural variations in keto-glutamines for improved inhibition against hepatitis A virus 3C proteinase • SHORT COMMUNICATION Rajendra P. Jain and John C. Vederas SummaryPlus | Full Text + Links | PDF (284 K) | |||
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Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors • SHORT COMMUNICATION Andrew Morrell, Smitha Antony, Glenda Kohlhagen, Yves Pommier and Mark Cushman SummaryPlus | Full Text + Links | PDF (292 K) | |||
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Antimitotic activity of glaupalol-related coumarins from Glaucidium palmatum • SHORT COMMUNICATION Hiroshi Morita, Tomoka Dota and Junichi Kobayashi SummaryPlus | Full Text + Links | PDF (340 K) | |||
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Optimization of 3-phenylpyrazolo[1,5-a]pyrimidines as potent corticotropin-releasing factor-1 antagonists with adequate lipophilicity and water solubility • SHORT COMMUNICATION Chen Chen, Keith M. Wilcoxen, Charles Q. Huang, James R. McCarthy, Takung Chen and Dimitri E. Grigoriadis SummaryPlus | Full Text + Links | PDF (275 K) | |||
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Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists • SHORT COMMUNICATION Xiao-Hua Jiang, Yan-Li Song and Ya-Qiu Long SummaryPlus | Full Text + Links | PDF (265 K) | |||
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Novel  2-isoxazolines as group II phospholipase A2 inhibitors • SHORT COMMUNICATIONBasappa, M. Satish Kumar, S. Nanjunda Swamy, M. Mahendra, J. Shashidhara Prasad, B. S. Viswanath and K. S. Rangappa SummaryPlus | Full Text + Links | PDF (254 K) | |||
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Synthesis and antiangiogenic activity of exo-olefinated deoxoartemisinin derivatives • SHORT COMMUNICATION Sangtae Oh, In Howa Jeong, Woon-Seob Shin and Seokjoon Lee SummaryPlus | Full Text + Links | PDF (265 K) | |||
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Design, synthesis and cytotoxic studies on the simplified oxy analog of eleutherobin • SHORT COMMUNICATION S. Chandrasekhar, V. Jagadeshwar, Ch. Narsihmulu, M. Sarangapani, D. R. Krishna, J. Vidyasagar, Dolly Vijay and G. Narahari Sastry SummaryPlus | Full Text + Links | PDF (275 K) | |||
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Design, synthesis, and biological evaluation of novel T-Type calcium channel antagonists • SHORT COMMUNICATION William F. McCalmont, Tiffany N. Heady, Jaclyn R. Patterson, Michael A. Lindenmuth, Doris M. Haverstick, Lloyd S. Gray and Timothy L. Macdonald SummaryPlus | Full Text + Links | PDF (272 K) | |||
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Inhibition of monoamine oxidases by coumarin-3-acyl derivatives: biological activity and computational study • SHORT COMMUNICATION Franco Chimenti, Daniela Secci, Adriana Bolasco, Paola Chimenti, Arianna Granese, Olivia Befani, Paola Turini, Stefano Alcaro and Francesco Ortuso SummaryPlus | Full Text + Links | PDF (344 K) | |||
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QSAR of adenosine receptor antagonists. Part 3: Exploring physicochemical requirements for selective binding of 1,2,4-triazolo[5,1-i]purine derivatives with human adenosine A3 receptor subtype • SHORT COMMUNICATION Kunal Roy, J. Thomas Leonard and Chandana Sengupta SummaryPlus | Full Text + Links | PDF (256 K) | |||
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Molecular modeling on DNA cleavage activity of seryl-histidine and related dipeptide • SHORT COMMUNICATION Ming Sun, Yuan Ma, Sanhao Ji, Huanai Liu and Yufen Zhao SummaryPlus | Full Text + Links | PDF (399 K) | |||
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Structure-based design of amidinophenylurea-derivatives for factor VIIa inhibition • SHORT COMMUNICATION Otmar Klingler, Hans Matter, Manfred Schudok, Monica Donghi, Joerg Czech, Martin Lorenz, Hans Peter Nestler, Hauke Szillat and Herman Schreuder SummaryPlus | Full Text + Links | PDF (326 K) | |||
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Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R) • SHORT COMMUNICATION Thomas H. Marsilje, Jonathan B. Roses, Emily F. Calderwood, Stephen G. Stroud, Nancy E. Forsyth, Christopher Blackburn, David L. Yowe, Wenyan Miao, Stacey V. Drabic, Marie D. Bohane et al. SummaryPlus | Full Text + Links | PDF (282 K) | |||
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Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis • SHORT COMMUNICATION Tianbao Lu, Thomas Markotan, Frank Coppo, Bruce Tomczuk, Carl Crysler, Stephen Eisennagel, John Spurlino, Lisa Gremminger, Richard M. Soll, Edward C. Giardino and Roger Bone SummaryPlus | Full Text + Links | PDF (313 K) | |||
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Glyco-optimization of aminoglycosides: new aminoglycosides as novel anti-infective agents • SHORT COMMUNICATION Sulan Yao, Paulo W. M. Sgarbi, Kenneth A. Marby, David Rabuka, Sean M. O'Hare, Mayling L. Cheng, Mrunali Bairi, Changyong Hu, San-Bao Hwang, Chan-Kou Hwang et al. SummaryPlus | Full Text + Links | PDF (302 K) | |||
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Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the  3 4* nicotinic acetylcholine receptors through modifications to the ester • SHORT COMMUNICATIONStephen C. Bergmeier, Khadiga A. Ismail, Kristjan M. Arason, Susan McKay, Darrell L. Bryant and Dennis B. McKay SummaryPlus | Full Text + Links | PDF (255 K) | |||
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Synthesis and antibacterial activity of O-substituted nocathiacin I derivatives • SHORT COMMUNICATION B. Narasimhulu Naidu, Margaret E. Sorenson, Thomas Hudyma, Xiaofan Zheng, Yunhui Zhang, Joanne J. Bronson, Michael J. Pucci, Junius M. Clark and Yasutsugu Ueda SummaryPlus | Full Text + Links | PDF (253 K) | |||
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Estrogen receptor ligands. Part 5: The SAR of dihydrobenzoxathiins containing modified basic side chains • SHORT COMMUNICATION Qiang Tan, Elizabeth T. Birzin, Wanda Chan, Yi Tien Yang, Lee-Yuh Pai, Edward C. Hayes, Carolyn A. DaSilva, Frank DiNinno, Susan P. Rohrer, James M. Schaeffer and Milton L. Hammond SummaryPlus | Full Text + Links | PDF (298 K) | |||
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Estrogen receptor ligands. Part 6: Synthesis and binding affinity of dihydrobenzodithiins • SHORT COMMUNICATION Qiang Tan, Elizabeth T. Birzin, Wanda Chan, Yi Tien Yang, Lee-Yuh Pai, Edward C. Hayes, Carolyn A. DaSilva, Frank DiNinno, Susan P. Rohrer, James M. Schaeffer and Milton L. Hammond SummaryPlus | Full Text + Links | PDF (250 K) | |||
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Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design • SHORT COMMUNICATION Jonna M. Lehtonen, Seppo Parkkila, Daniela Vullo, Angela Casini, AndreaScozzafava and Claudiu T. Supuran SummaryPlus | Full Text + Links | PDF (328 K) | |||
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Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa • SHORT COMMUNICATION Werner W. K. R. Mederski, Dieter Dorsch, Soheila Anzali, Johannes Gleitz, Bertram Cezanne and Christos Tsaklakidis SummaryPlus | Full Text + Links | PDF (434 K) | |||
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A new family of quinoline and quinoxaline analogues of combretastatins • SHORT COMMUNICATION Concepción Pérez-Melero, Ana B. S. Maya, Benedicto del Rey, Rafael Peláez, Esther Caballero and Manuel Medarde SummaryPlus | Full Text + Links | PDF (306 K) | |||
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Structure–activity relationships of adenosine A3 receptor ligands: new potential therapy for the treatment of glaucoma • SHORT COMMUNICATION Takashi Okamura, Yasuhisa Kurogi, Kinji Hashimoto, Seiji Sato, Hiroshi Nishikawa, Kimio Kiryu and Yoshimitsu Nagao SummaryPlus | Full Text + Links | PDF (271 K) | |||
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(+)-3-[2-(Benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane as potent agonists for the 7 nicotinic acetylcholine receptor • SHORT COMMUNICATION Ryo Tatsumi, Kohji Seio, Masakazu Fujio, Jiro Katayama, Takashi Horikawa, Kenji Hashimoto and Hiroshi Tanaka SummaryPlus | Full Text + Links | PDF (282 K) | |||
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Synthesis of a bromotyrosine-derived natural product inhibitor of mycothiol-S-conjugate amidase • SHORT COMMUNICATION Brandon Fetterolf and Carole A. Bewley SummaryPlus | Full Text + Links | PDF (261 K) | |||
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Specific inhibition effects of N-pentafluorobenzyl-1-deoxynojirimycin on human CD4+ T cells • SHORT COMMUNICATION Xiao-Lian Zhang, Min Liu, Peng Xie, Shuhui Wan, Jia Tao Ye, Xiang Zhou and Jianguo Wu SummaryPlus | Full Text + Links | PDF (269 K) | |||
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Structure–affinity relationships of 5′-aromatic ethers and 5′-aromatic sulfides as partial A1 adenosine agonists, potential supraventricular anti-arrhythmic agents • SHORT COMMUNICATION Christopher F. Morrison, Elfatih Elzein, Bob Jiang, Prabha N. Ibrahim, Timothy Marquart, Venkata Palle, Kevin D. Shenk, Vaibhav Varkhedkar, Tenning Maa, Lin Wu et al. SummaryPlus | Full Text + Links | PDF (264 K) | |||
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Synthesis and structure–activity relationship of novel benzoxazole derivatives as melatonin receptor agonists • SHORT COMMUNICATION Li-Qiang Sun, Jie Chen, Marc Bruce, Jeffrey A. Deskus, James R. Epperson, Katherine Takaki, Graham Johnson, Lawrence Iben, Cathy D. Mahle, Elaine Ryan and Cen Xu SummaryPlus | Full Text + Links | PDF (258 K) | |||
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DNA sequence recognition in the minor groove by hairpin pyrrole polyamide–Hoechst 33258 analogue conjugate • SHORT COMMUNICATION Putta Mallikarjuna Reddy, Rachel Dexter and Thomas C. Bruice SummaryPlus | Full Text + Links | PDF (331 K) | |||
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Synthesis and antibacterial activity of novel bifunctional macrolides • SHORT COMMUNICATION Irini Akritopoulou-Zanze, Kathleen M. Phelan, Thomas G. Marron, Hong Yong, Zhenkun Ma, Greg G. Stone, Melissa M. Daly, Dena M. Hensey, Angela M. Nilius and Stevan W. Djuric SummaryPlus | Full Text + Links | PDF (283 K) | |||
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Synthesis of a key Mycobacterium tuberculosis biosynthetic phosphoinositide intermediate • SHORT COMMUNICATION K. N. Jayaprakash, Jun Lu and Bert Fraser-Reid SummaryPlus | Full Text + Links | PDF (301 K) | |||
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Amidine derived 1,3-diazabuta-1,3-dienes as potential antibacterial and antifungal agents • SHORT COMMUNICATION Preet M. S. Bedi, Mohinder P. Mahajan and Vijay K. Kapoor SummaryPlus | Full Text + Links | PDF (246 K) | |||
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Novel dual inhibitors of calpain and lipid peroxidation • SHORT COMMUNICATION Serge Auvin, Bernadette Pignol, Edith Navet, Dominique Pons, Jean-G. Marin, Dennis Bigg and Pierre-E. Chabrier SummaryPlus | Full Text + Links | PDF (251 K) | |||
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Design, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents • SHORT COMMUNICATION U. Sharma, J. C. Marquis, A. Nicole Dinaut, S. M. Hillier, B. Fedeles, P. T. Rye, J. M. Essigmann and R. G. Croy SummaryPlus | Full Text + Links | PDF (337 K) | |||
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Quinoxaline N,N′-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi. Structure–activity relationships • SHORT COMMUNICATION Gabriela Aguirre, Hugo Cerecetto, Rossanna Di Maio, Mercedes González, María Elena Montoya Alfaro, Andrés Jaso, Belén Zarranz, Miguel Ángel Ortega, Ignacio Aldana and Antonio Monge-Vega SummaryPlus | Full Text + Links | PDF (288 K) | |||
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Yeast and mammalian -glucosidase inhibitory constituents from Himalayan rhubarb Rheum emodi Wall.ex Meisson • SHORT COMMUNICATION K. Suresh Babu, Ashok K. Tiwari, Pullela V. Srinivas, Amtul Z. Ali, B. China Raju and J. Madhusudana Rao SummaryPlus | Full Text + Links | PDF (349 K) | |||
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Editorial board • MISCELLANEOUS PDF (274 K) | |||
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Contributors to this issue • MISCELLANEOUS PDF (189 K) | |||
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Instructions to contributors • PUBLISHER'S NOTE PDF (70 K) | |||
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